Tatsuki Miyamoto

Two potent, functionally redundant MazF toxins inactivate the 16S rRNA anti-Shine-Dalgarno sequence and are differentially expressed in Mycobacterium tuberculosis

Mycobacterium tuberculosis (Mtb) remains a major global health threat, sustained by lengthy, multidrug treatment regimens that promote poor compliance and antibiotic resistance. The pathogen’s ability to evade clearance is facilitated in part by a transition to a nonreplicating, persistent state, a process thought to i...