Tatsuro Goda

Phospholipid-Mimetic Amphiphilic Polyion Complexes Enable Intracellular Oligonucleotide Delivery under Charge-Neutral Conditions.

Here, we report phospholipid-mimetic cationic copolymers that facilitate intracellular oligonucleotide delivery at a net charge-neutral polymer/DNA mixing ratio. Conventional nucleic acid delivery nanocarriers are mainly internalized through endocytosis, which often leads to endosomal sequestration and nucleic acid deg...