Elucidation of the Biosynthesis of Pantocin A.
Pantocin A is a ribosomally synthesized, post-translationally modified peptide (RiPP) natural product that exhibits antibiotic activity through the inhibition of histidine biosynthesis. The gene cluster that gives rise to pantocin A contains genes for two putative biosynthetic enzymes, PaaA and PaaB. PaaA has previousl...