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Author

Ted M. Dawson

2 papers indexed here

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Review Sep 2026

ZIPPing the gaps: A new class of zinc finger proteins orchestrates the DNA damage response.

Maintaining genomic integrity is fundamental to cellular survival, the prevention of cancer and other pathologies. Central to this protective system is the DNA damage response (DDR), governed by an intricate cascade of post-translational modifications, among which poly(ADP-ribosylation) (PARylation) stands out for its...

Louis Nonfoux, J. Gagné, Bong-Gu Kang et al. · 0 citations
Open access Jul 2026

Targeted α-synuclein mRNA degradation by PMO-based RNA-degrading chimeras.

Findings indicate that PMO-based RNA-degrading chimeras (RDCs) that selectively bind the 5' untranslated region of SNCA messenger RNA (mRNA) and recruit RNase L for targeted RNA degradation may represent a promising therapeutic modality for α-synucleinopathies.

Ning Wang, Shalakha Hegde, Zhichao Tang et al. · 0 citations

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