JOSD2 attenuates the aggressive behavior of fibroblast-like synoviocytes in rheumatoid arthritis by deubiquitinating and stabilizing ZNF148.
BACKGROUND Activated fibroblast-like synoviocytes (FLS) significantly promote synovial inflammation and bone destruction in rheumatoid arthritis (RA). Emerging evidence illustrates that ubiquitination significantly drives both inflammatory processes and the regulation of immunity. This study aimed to elucidate the role...