Tengku Anggia Fitri

Design and mechanistic evaluation of chalcone–quinoline–triazole hybrids as antifungal CYP51 inhibitors

A series of novel chalcone–quinoline–triazole hybrid compounds were rationally designed, synthesised, and evaluated for antifungal activity against clinically relevant Candida species, including C. albicans, C. glabrata, and C. krusei. Among the synthesized derivatives, compound 7b exhibited the most potent antifungal...