Author

Tereza Clarence

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Open access Sep 2026

Lifespan single-cell transcriptomic atlas of the human prefrontal cortex

The human brain undergoes profound changes from early development through late adulthood, shaping cognition, behaviour and vulnerability to disease1,2. Understanding how these changes are organized within specific brain regions and cell types is essential for interpreting normal ageing and its relationship to psychiatr...

Hui Yang, Tereza Clarence, Madeline R. Scott et al. · Nature · 3 citations

Open access Sep 2026

Single-cell atlas of transcriptomic vulnerability across brain disorders

Neurodegenerative and neuropsychiatric diseases impose a considerable societal and public health burden. However, our understanding of the molecular mechanisms underlying these highly complex conditions remains limited1,2. Here, to gain deeper insights into the aetiology of different brain diseases, we used specimens f...

Donghoon Lee, Mikaela Koutrouli, Nicolas Y. Masse et al. · Nature · 5 citations