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Tess Lamer

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Open access Jul 2026

Identification of a Potent Pan-Coronaviral Main Protease Inhibitor.

A covalent pan-coronaviral inhibitor that targets 19 Mpros across the α, β, γ, and δ genera, encompassing bat, human, and other animal coronaviruses, AVI8122 exhibits low nanomolar potency and favorable pharmacokinetics in mice and is positioned as an early lead compound and a tractable structural starting point for th...

Pu Chen, Ulrike Strunk, E. Arutyunova et al. · 0 citations

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