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The Global Parkinson's Genetics Program

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Open access Oct 2026

TMEM106B analysis in diverse cohorts suggests no association with Parkinson's disease risk

Recent evidence suggests that TMEM106B expression is reduced in the brains of patients with Parkinson's disease (PD). However, an association between rare genetic variants in TMEM106B and PD risk has not been previously established. In this work, we investigated the association between rare TMEM106B variants and PD ris...

H. M. Chaparro Solano, S. Kanagasingam, Z. Gan-Or et al. · medRxiv · 0 citations

Open access Sep 2026

Lysosomal polygenic risk score in Parkinson's disease across populations.

Background: Lysosomal dysfunction has been implicated in Parkinson's disease (PD) pathogenesis. However, lysosomal polygenic risk scores (lyso-PRS) have not been evaluated extensively in PD across populations. Objectives: (1) Evaluation of lyso-PRS (lyso-PRS) performance for PD risk across populations; (2) Comparison o...

W. Sun, K. Brockmann, I. Wurster et al. · medRxiv · 0 citations