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Theodore J. Nettleton

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Review Open access Sep 2026

Tools to investigate class B1 GPCR conformational landscapes with cryo-EM and beyond.

G protein-coupled receptors (GPCRs) are membrane proteins that act as signal transducers across cell membranes. Class B1 GPCRs, a subset of 15 receptors activated by peptide hormones, are involved in important physiological processes and diseases, making them a popular target for drug development. GPCRs are dynamic pro...

Theodore J. Nettleton, P. M. Sexton, D. Wootten et al. · 0 citations

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