Author

Theodore J. Price

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Open access 2022

Basic mechanisms and pathophysiology

The ability to experience pain is essential for survival and wellbeing and the pathological consequences of the inability to experience pain are particularly well-illustrated by the extensive injuries experienced by children with congenital insensitivity to pain. In this chapter, the authors focus on the molecules and...

M. Yousuf, Allan I. Basbaum, Theodore J. Price · Clinical Pain Management · 0 citations

Open access Sep 2026

NaV1.7-dependent peripheral sensitization drives chronic pain in Parkinson’s disease

Pain is among the most prevalent and disabling nonmotor symptoms of Parkinson’s disease (PD), yet its mechanisms remain poorly defined and effective treatments are limited. Safinamide is one of the few drugs reported to improve pain in PD, but the mechanism underlying this effect is unknown. Here, we show that nigrostr...

Tyler S. Nelson, Naomi K. Grabus, Heather N. Allen et al. · bioRxiv · 1 citation

Open access Sep 2026

Chronic lower limb pain is not associated with a loss of inhibitory neurons in the human lumbar spinal dorsal horn

The spinal dorsal horn is the primary processing site of nociceptive sensory input from the periphery. Excitatory spinal interneurons releasing glutamate can amplify this information before it is sent to the brain, whereas inhibitory neurons releasing GABA and/or glycine can suppress the outflow of nociceptive signals....

Olivia C. Davis, Jane M. Brandon, Keerthana Natarajan et al. · bioRxiv · 0 citations