Review
Open access
Oct 2026
Molecular mechanisms underpinning cognitive reserve and resilience
The concept of cognitive reserve (CR) and resilience originates from clinicopathological observations that amyloid-β deposition, tau pathology and neurodegeneration do not uniformly translate into clinical dementia, highlighting inter-individual differences in the brain’s capacity to tolerate pathology. Although CR and...
Amber Chen, Sreenithi Bhuvaneshwaran, Y. Akkara et al.
· Frontiers in Aging Neuroscie... · 0 citations