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Author

Thomas Carell

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3 papers indexed here

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Open access Oct 2026

The tRNA-Modification Geranyl-2-Thiouridine Enables RNA-Lipid Association.

The packaging of RNA in lipid nanoparticles for protection and delivery was key for the development of mRNA vaccines and therapeutics. Formulation requires the addition of a variety of lipids (including cationic) in high amounts to form complexes with the negatively charged RNA. While this approach was successful for t...

Johannes Singer, Kathrin Halter, Chun-Yin Chan et al. · 0 citations
Open access Aug 2026

Selective oxidation and quantification of m5C in ribonucleosides and RNA in an epigenetic context

Selective modification of methylated bases in RNA and DNA is central to the field of epigenetics and furthermore fundamental for developing next-generation sequencing and liquid biopsy applications. While in DNA the detection and modification of 5-methylcytidine (5mdC) is fairly advanced, current strategies for detecti...

Kora Holschbach, T. Walter, Davide Guglielminotti et al. · 0 citations
Aug 2026

Global Incorporation of a Photo-Cross-Linking Amino Acid to Probe the Protein Interactome under Physiological Conditions.

Proteome-wide incorporation of DizPK, a diazirine-containing lysine analog with a dedicated MS-cleavable urea functionality, is demonstrated via stochastic orthogonal recoding of translation and subsequent identification of photo-cross-linked peptides to map protein-protein interactions under physiological conditions.

Piyoosh Sharma, Divya Yadav, Anneliese M. Faustino et al. · 0 citations

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