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Author

Thomas Fehr

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Open access Oct 2026

Short-term effects of an SGLT2 inhibitor on divalent ions in autosomal dominant polycystic kidney disease: a randomized crossover trial

No substantial short-term difference in urinary or fractional excretion of divalent ions were detected with empagliflozin in this exploratory mechanistic trial, and the observed changes in serum magnesium, urinary citrate, uric acid, and copeptin are hypothesis-generating and require confirmation in larger, longer-term...

L. Roth, D. Harmacek, T. Schachtner et al. · 0 citations
Sep 2026

Unanticipated global emergence and evolution of Pneumocystis jirovecii mutations and resistance driven by a human-targeted drug.

Nearly all known cases of antimicrobial resistance have been linked to agents that directly target microbes. This paradigm overlooks other drivers of microbial evolution and resistance. Here, we report compelling evidence of resistance-associated mutations in Pneumocystis jirovecii, a high-priority fungal pathogen desi...

Liang Ma, Ming Hao, Wei-Zhong Chang et al. · 0 citations

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