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Thomas Lubinski

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Preprint Sep 2026

Parallel Circuit Execution for Scalable Quantum Computation

Today's quantum processors have tens to hundreds of physical qubits, but reliable execution of arbitrary circuits remains limited to fewer than 30 entangled qubits across hardware modalities. Building upon prior work, we introduce an error- and topology-aware method for mapping multiple independent circuits onto disjoint regions of a single large-scale QPU for parallel circuit execution. For applications with many similarly sized circuits, such as observable estimation for Hamiltonian simulation, this approach can reduce billed QPU execution time, with ideal speedup proportional to the number of usable partitions. We demonstrate the approach on IBM's 156-qubit ibm_boston processor using standard QED-C benchmark and Hamiltonian-based observable-estimation workloads. Compared with standard sequential execution, parallel execution reduces billed execution time by 3.5-5.5x while retaining 83-92% of the sequential fidelity. We further evaluate the scaling of parallel circuit execution using GPU-accelerated classical simulation, distributing measurement circuits across GPUs via MPI. Using CUDA-Q on the NERSC Perlmutter system, we achieve up to 13.8x speedup on 16 GPUs (86% parallel efficiency) for an H2 electronic-structure simulation, with scaling evaluated across multiple Hamiltonians and circuit counts. These results provide an indication of the performance ceiling that parallel execution on future quantum hardware may eventually approach. Both execution modes are implemented as a runtime option within the QED-C Application-Oriented Benchmark suite. Together, the results show that circuit-level parallelism can reduce execution cost on current quantum hardware and simulation time on GPU clusters, with the potential for greater benefits as device quality and qubit counts increase.

Avimita Chatterjee, W. M. Brown, Si-Yuan Niu et al. · 0 citations
Preprint Aug 2026

Benchmarking Quantum and Classical Machine Learning Models on Oncological Data

Machine learning is being increasingly used for the detection, diagnosis, and treatment of cancer. However, models often struggle with biological data due to high dimensionality, limited sample diversity, and complex feature interactions. Recent works have investigated the potential for quantum machine learning models to exhibit improved performance over classical models on this kind of complex data, but have often lacked rigorous empirical evaluation of quantum advantage. In this work, we develop a methodology for fair benchmarking of quantum and classical machine learning models, based on the Red Cedar quantum machine learning and resource estimation framework and AutoML-optimized classical neural networks. We assess the potential for quantum advantage in machine learning across tabular, omics, and spatial oncological datasets drawn from the existing quantum machine learning literature, with a range of preprocessing methods, and find no evidence of quantum advantage. Our results suggest that the field should prioritize analyzing higher-dimensional, more biologically realistic datasets to make meaningful progress toward practical quantum advantage in oncological classification problems.

Sydney Leither, Thomas Lubinski, Michael Kubal et al. · 0 citations

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