Author

T. Cappola

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Open access Nov 2026

Early Increases in GDF-15 Are Associated With Declines in Cardiac Function With Breast Cancer Therapy.

BACKGROUND Growth differentiation factor (GDF)-15 is a stress-responsive cytokine induced by mitochondrial dysfunction and genotoxic stress, mechanisms central to anthracycline cardiotoxicity. Whether early changes in GDF-15 following cancer therapy relate to subsequent cardiac dysfunction is not established. OBJECTI...

N. Wilcox, Cong-Ying Xia, Wei Yang et al. · JACC: Advances · 0 citations

Open access Aug 2026

Pathway Modeling of Genomic and Tissue-Specific Transcriptomic Architecture Identifies Personalized Mechanisms of Atrial Fibrillation Risk

A pathway-level multi-omics representation learning framework that converts individual genetic profiles into interpretable biological features by integrating GWAS-derived pathway burden scores with tissue-specific transcriptomic pathway signals is developed, providing a framework for interpretable genomic stratificatio...

R. Venkatesh, R. Deo, T. Cappola et al. · medRxiv · 0 citations