Author

Thomas Sauter

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Open access Sep 2026

Accessing Enzyme Kinetic Data and Prediction Methods at Scale

Enzyme kinetic parameters inform metabolic models, yet experimental measurements are sparse. A growing body of work predicts them from protein and substrate features, but software fragmentation hinders adoption, so downstream tools lock into the most accessible method. We present OpenKinetics Predictor (predictor.openk...

Saleh Alwer, Hugues Escoffier, Karim Taha et al. · bioRxiv · 0 citations

Open access Aug 2026

Crosstalk between S-nitrosylation and glycation defines a metabolic vulnerability in liver and renal cancers

It is demonstrated that pharmacological inhibition of the glyoxalase system—the major pathway for MGO detoxification—restores drug sensitivity in patient-derived cells and xenograft models, revealing a context-dependent metabolic vulnerability in AKR1A1 loss conditions.

Chiara Pecorari, Mojca Bratina, Evelyn Gonzalez et al. · Nature Communications · 1 citation

Open access Jul 2026

WILDkCAT: extract, retrieve, and predict enzyme turnover numbers of constraint-based metabolic models

The ability of WILDkCAT to retrieve substantial kcat coverage and its applicability across diverse genome-scale models demonstrated the ability of WILDkCAT to retrieve substantial kcat coverage and its applicability across diverse genome-scale models.

Hugues Escoffier, Carole L. Linster, Thomas Sauter · Bioinform. · 1 citation