Author

Tian Huang

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Open access Sep 2026

MAL2-Driven Lipid Droplets as Trojan Horses: Subverting Immune Surveillance to Promote Colorectal Cancer Liver Metastasis.

Colorectal cancer liver metastasis (CRLM) represents a formidable clinical challenge, yet the metabolic mechanisms by which tumor cells dismantle hepatic immune surveillance and remodel the tumor microenvironment (TME) remain elusive. Here, integrating single-cell RNA sequencing (scRNA-seq), transcriptomic analysis, an...

Shi-Peng Dai, Zi-Yuan Liu, Jun-Jie Sun et al. · Cancer Letters · 0 citations

Open access Aug 2026

Machine Learning-Guided Personalized Immunochemotherapy Strategies in Intrahepatic Cholangiocarcinoma.

BACKGROUND & AIMS Immunochemotherapy (IO-chemo) has become standard care for patients with unresectable intrahepatic cholangiocarcinoma (iCCA), but benefit of adding IO varies greatly among individuals. We sought to develop a system to identify patients most likely to benefit from this treatment based on individualized...

Jun-Hao Mei, Kai Zhang, Ying Zhang et al. · JHEP Reports · 0 citations