Author

Tianle Zhou

2 papers indexed here

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Open access Sep 2026

Proteome-wide Mendelian randomization and transcriptome analysis of a novel osteoarthritis blood-targeting USP8, single-cell model and experimental validation.

BACKGROUND Osteoarthritis (OA) is the most common chronic joint disorder and greatly affects quality of life and increases socioeconomic burden; however, effective prevention is limited. Blood proteins with established causal evidence can probably serve as potential drug targets, but few have been causally linked with...

Qi-Wang He, Yue Liu, Xi-Ming Liu et al. · International Immunopharmaco... · 0 citations

Jul 2026

Exploring the Potential Mechanism of Isoliquiritigenin in the Treatment of Osteoarthritis through Integrated Network Pharmacology, Molecular Docking, and Experimental Validation.

INTRODUCTION Osteoarthritis (OA) is a prevalent and chronic joint disease characterized by progressive cartilage degeneration and chronic inflammation. Isoliquiritigenin (ISL), a bioactive flavonoid derived from licorice, has demonstrated significant anti-inflammatory potential in various diseases. However, its specifi...

Wei Wang, Qiwang He, Zhiwen Zhang et al. · Combinatorial chemistry & hi... · 0 citations