Identification of a novel nucleolin-binding aptamer for specific tissue recognition and targeted drug delivery in esophageal squamous cell carcinoma.
Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive malignancies, characterized by a poor prognosis largely attributable to the lack of early diagnostic markers and targeted therapeutic agents. Aptamers, screened through the Cell-based Systematic Evolution of Ligands by Exponential Enrichment (Cell-...