Aug 2026
BLTP2 bridges the ER and MVB for exosome biogenesis at SCAMP3-dependent ER contacts.
Multivesicular bodies (MVBs) contain intraluminal vesicles (ILVs) designated for degradation in lysosomes or release as exosomes for cell-to-cell communication. The mechanisms governing ILV/exosome formation are not fully understood. Here, we show that the integral endoplasmic reticulum (ER) membrane protein bridge-lik...
Jingru Wang, Dongchen Li, Yazhou Liu et al.
· Current Biology · 0 citations