Review
Open access
Sep 2026
Resting-State Functional Connectivity Alterations in Insomnia Disorder: A Systematic Review of Studies Published from 2020 to July 2025
The overall pattern is compatible with hyperarousal, but both increased and decreased connectivity were reported; diagnostic definitions, sex, symptom severity and duration, medication exposure, acquisition conditions, and seed-based versus data-driven analyses may moderate direction and magnitude.
Ya-Ni Zhang, Yi-Wen Zhang, Cai-Li Shi et al.
· Nature and Science of Sleep · 0 citations