Large language models can describe mechanisms, yet scalable post-training still depends on costly, manually curated biological reasoning traces. Here we show that cellular perturbation atlases can instead become reinforcement-learning environments, where measured gene responses provide computable rewards for biological...
Zhen-Chao Tang, Xiaogang Xu, Tian-Xu Lv et al.· 0 citations
This work introduces TCRTSdesign, a framework that concurrently generates novel TCR sequences with specific binding capabilities to target pMHC molecules and predicts the full-atom structures of the TCR-pMHC complex, while optimizing their binding affinity.
Yang Xiao, Yu Zhao, Fandi Wu et al.· Proceedings of the 32nd ACM...· 0 citations
Biomolecular binder design for peptides and antibodies requires generating diverse candidates that satisfy stringent three-dimensional geometric constraints while enabling affinity-oriented exploration under strong structural priors. In current generative models, the effective search space for structurally feasible bin...
Zhihua Tian, Jiale Zhou, Rubo Wang et al.· Proceedings of the 32nd ACM...· 0 citations
Designing functional T cell receptors (TCRs) for a given peptide presented by MHC (pMHC) is an emerging yet highly challenging problem in computational immunology. While recent approaches have achieved initial progress, they face two major limitations: (1) the lack of structural information from TCR–pMHC complexes in t...
Yang Xiao, Yu Zhao, Fandi Wu et al.· Proceedings of the 32nd ACM...· 0 citations
Branch-JEPA is introduced, which replaces this point-valued transition with a context-weighted finite set of latent successors, and preserves more distinct futures, while full-set scoring improves the quality of the resulting predictive distribution.
Zhi Song, Ximing Xing, Zhenchao Tang et al.· 0 citations
Semantics-Preserving Exploratory Sampling (SPES), which integrates Graph Laplacian Spectral Noise to respect chain connectivity and Conditional Freedom Modulation to dynamically balance exploration with fidelity, enables diversity-enhanced generation without sacrificing geometric validity under the reported structural...
Zhihua Tian, Jiale Zhou, Rubo Wang et al.· Proceedings of the 32nd ACM...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
