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Author

Tian-Yi Zhang

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Jul 2026

SHMT2 Regulates T Cell Homeostasis and Mucosal Inflammation Via Metabolic and Lipid Remodeling 2256280

The loss of SHMT2 in T cells disrupted mitochondrial one-carbon metabolism, induced redox imbalance and enhanced neutral lipid storage and phospholipid synthesis, with compensatory arginine-proline upregulation and taurine depletion to sustain survival under oxidative stress.

Lamis El-Baz, Michael C. McGee, Rezwanul Islam et al. · 0 citations
Open access Jul 2026

Intranasal exposure to SARS-CoV-2 spike protein induces Th2 and Th17 cell-associated pulmonary immunopathology 2258252

Intramuscular mRNA vaccines show superior safety, while spike contains epitopes capable of driving Th2- and Th17-mediated pathology, highlighting the need to refine spike antigens and booster strategies for durable, safe protection.

Tian-Yi Zhang, Nicholas Magazine, Lamis El-Baz et al. · 0 citations

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