Author

Tian-Yu Gao

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Open access Aug 2026

A dual-action humanized DKK-1 antibody that activates the Wnt/β-catenin signaling pathway and inhibits the RANKL signaling pathway for osteoporosis therapy

Introduction Osteoporosis remains a major global health challenge, and current single-pathway therapies often fail to achieve coordinated bone remodeling. Dickkopf-1 (DKK-1) is a potent inhibitor of the Wnt/β-catenin signaling pathway and plays a critical role in osteoporotic bone loss. Neutralization of DKK-1 represen...

Sheng Hou, Tian-Yu Gao, Yi-Mei Wu et al. · Frontiers in Immunology · 0 citations

#machine learning Preprint Aug 2026

Language-Informed Flow Matching for Trend-Guided Structure-Based 3D Molecular Generation

LiFT, a language-informed cross-modal framework built on Flow Matching for trend-guided 3D molecular generation across both de novo design and scaffold hopping, and suggests that language-derived chemical priors provide effective trend-level guidance for 3D molecular generation.

Tian-Yu Gao, Zhi-Kai Su, Jia-Shu Li et al. · 0 citations