Author

Tianbao Chen

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Open access Aug 2026

Identification and Structure–Activity Relationship of a Novel Dermatoxin-like Antimicrobial Peptide with Partial LPS-Mediated Membrane Interaction

It is suggested that protease cleavage-guided truncation may represent a useful strategy for developing shorter and safer antimicrobial peptides, resulting in an improved selectivity profile.

Shiya Cheng, Zai Yu, Jiayi Peng et al. · Molecules · 0 citations

Open access Aug 2026

Balancing Cationicity and Hydrophobicity in Dermaseptin-A4 Generates a Selective Antimicrobial Peptide with Enhanced Therapeutic Potential

It is demonstrated that achieving an optimal balance between peptide hydrophobicity and cationicity is an effective strategy for enhancing antimicrobial selectivity without compromising antibacterial activity, highlighting A4-3 as a promising lead candidate for the development of novel antimicrobial therapeutics agains...

Wei-Chang Li, Wu-Di Wang, Bo-Lin Chen et al. · Antibiotics · 0 citations