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Author

Tianji Zhang

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Open access Oct 2026

Heparan Sulfate Oligosaccharides Modulate SARS-CoV-2 Spike-Host Recognition.

Heparan sulfate (HS) is a key host-factor mediator of SARS-CoV-2 attachment and an attractive target for antiviral intervention, yet the synthesis of structurally defined HS oligosaccharides remains challenging. Here, we show that a defined HS hexasaccharide, heparin-dp6, efficiently inhibits RBD-ACE2 binding and exhib...

Bin-Jie Li, Tian-Ji Zhang, Ming-Jia Yu · 0 citations
Aug 2026

Systematic Virtual Screening of Heparan Sulfate Oligosaccharides and Mechanistic Insights into Heparanase Inhibition

Heparanase (Hpse) is an endo-β-glucuronidase that specifically cleaves heparan sulfate (HS) and plays critical roles in the pathogenesis of multiple diseases, making it a well-validated therapeutic target. To identify novel Hpse inhibitors, we developed a rule-based computational pipeline to construct a rigorously cu...

Binjie Li, Siran Zhao, Zonglin Lan et al. · 0 citations

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