Amino acid substitutions at the G118 hotspot in dihydroorotate dehydrogenase confer olorofim resistance in Aspergillus flavus
ABSTRACT The clinical management of invasive aspergillosis (IA) is limited by the scarcity of antifungal agents and the emergence and spread of drug resistance, which impairs therapeutic efficacy and poses a significant public health threat. Olorofim, a first-in-class clinical antifungal targeting dihydroorotate dehydr...