Open access
Sep 2026
Bacterial Peptidoglycan Extends Lifespan by Activating Lysosomal Activity through V-ATPase Binding
Findings reveal an evolutionarily conserved mechanism whereby hosts exploit bacterial cell wall components to maintain cellular homeostasis, establishing a gut microbiome–lysosome–longevity axis with implications for microbiome-based anti-aging interventions.
He-Rui Fu, Tie Jia, Yan Zhou et al.
· bioRxiv · 0 citations