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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Tiejun Bing

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2 papers indexed here

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Jul 2026

Abstract A068: Multi-omics validated KRASi-resistant cell lines for combination and sequential drug treatment discovery

Despite the transformative efficacy of KRAS inhibitors in KRAS-mutant malignancies, intrinsic refractoriness and adaptive resistance markedly impair durable treatment responses. Preclinical models that recapitulate the molecular heterogeneity and evolutionary features of clinical resistance are therefore essentia...

Liuxian Meng, Yingxin Bi, Xinuo Zhang et al. · 0 citations
Jul 2026

Abstract B040: Hold-to-Kill: RIPTAC Expanding Induced Proximity from Target Engagement to Therapeutic Window

RIPTAC (Regulated Induced Proximity Targeting Chimeras) introduces a novel strategy that leverages induced proximity to achieve selective cancer cell killing. Using AR-BRD4 RIPTAC II-5 as a tool compound, we integrated biochemical screening, computational docking, and multi-level cellular and in vivo assays to establ...

Qing Xue, Zhuo Meng, Xuebing Yang et al. · 0 citations

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