Tim Clausen

Structures of the UBR4 complex reveal a giant arena to capture diverse substrates for ubiquitin chain elongation.

Ubiquitin ligases, members of the protein quality control machinery, target misassembled, and mislocalized proteins for degradation by tagging them with ubiquitin. The giant ubiquitin ligase UBR4 has emerged as a central regulator of protein fate by selecting a wide range of ubiquitinated protein substrates and extendi...