Open access
Jul 2026
A Comprehensive 19F NMR Framework for Fragment-Based Drug Discovery: The Validated Screening Library OpenFL600 and Efficient Affinity Ranking by CSAR.
The design and validation of a non-proprietary 19 F NMR screening library (OpenFL600) capable of probing diverse binding pockets, as demonstrated for RNA, G protein-coupled receptors, kinases, protein-protein interactions, and proteases is presented.
S. Rüdisser, Gabriela R. Stadler, G. Padroni et al.
· Angewandte Chemie · 0 citations