Author

Timothy H. Tran

2 papers indexed here

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Open access Aug 2026

C-terminus CD28 phosphorylation, Y218, modulates IL-2 secretion and therapeutic effect of CAR-T cells.

CD28 is a co-stimulatory component of several second-generation chimeric antigen receptor (CAR)-T cells, providing signals essential for T cell proliferation, survival, and cytokine secretion. However, the specific contribution of individual CD28 intracellular motifs to CAR-T cell function remains incompletely understo...

Elena Martinez-Planes, M. C. Ramello, Miguel G. Fontela et al. · Molecular Therapy · 0 citations

Open access Aug 2026

Unc-51 like kinase 3 (ULK3) contributes to autophagy and cell survival in multiple myeloma

It is found that ULK3 contributes to autophagy and supports MM cell survival and calls for future development of more selective ULK3-directed therapies, calling for future development of more selective ULK3-directed therapies.

Marilena Tauro, Tao Li, P. Sudalagunta et al. · Nature Communications · 0 citations