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Author

Timothy Palzkill

1 paper indexed here

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Aug 2026

Mechanistic Roles of Conserved Active-Site Residues in OXA-48 Carbapenem Hydrolysis.

Carbapenem-hydrolyzing class D β-lactamases are a major source of resistance to last resort β-lactam antibiotics. OXA-48 is a class D β-lactamase that hydrolyzes carbapenems through a catalytic mechanism involving a nucleophilic serine and a carboxylated lysine general base. To define the contributions of conserved act...

DorisMia Taylor, D. Ngango, Jia-Yi Fan et al. · 0 citations

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