A systematic effort to determine the sequence specificity of 332 putative and poorly characterized human TFs is described, which reveals tens of thousands of previously unknown, conserved and direct TF-binding sites across the human genome.
A. Jolma, Kaitlin U. Laverty, Ali Fathi et al.· Nature· 3 citations
There is ongoing debate regarding the degree to which transcription factors (TFs) independently specify genomic binding: TF binding motifs are typically short and degenerate, yielding many more binding site predictions than observed in cells. Here we present genomic high-throughput SELEX (GHT-SELEX)—a scalable method t...
A. Jolma, A. Hernandez-Corchado, A. Yang et al.· Nature Methods· 3 citations
A post-transcriptional regulatory pathway in which Pumilio and Brain tumor ensure orderly progression of the Drosophila maternal-to-zygotic transition by clearing smaug mRNA and preventing ectopic Smaug activity is defined.
A. Marsolais, Mariana Kekis, Harrison W Smith et al.· bioRxiv· 0 citations
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