Structural Mass Spectrometry Resolves the Conformational Dynamics of Semaglutide Oligomerization
Recent studies showed that several widely used glucagon-like peptide-1 receptor agonists (GLP-1RAs) can self-assemble into dynamic oligomeric species and ultimately less-regular, non-amyloid aggregates. While mature aggregates can be characterized by high-resolution microscopy methods, probing the conformational dyna...