Ting-Chen Tian

Turn Shield into Sword: Pathological Hydroxyapatite-Targeting Micelles Drive Metabolic Stress-Induced Autophagy Dysfunction for Bone Metastasis Therapy

Bone metastasis remains a major clinical challenge in advanced breast cancer because therapeutic efficacy is limited by poor lesion targeting and systemic toxicity. Moreover, the hypoxic bone microenvironment induces protective autophagy in tumor cells, which maintains metabolic homeostasis and limits therapeutic eff...