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Ting-Ting Chen

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Review Sep 2026

A Unified Mechanistic Framework for Copper Toxicity in Neutrophils: Metabolic Rewiring, Cell-Death Crosstalk, and Immune Dysfunction.

SIGNIFICANCE Copper is an essential redox-active micronutrient, but failure of copper compartmentalization can convert it from a catalytic cofactor into a source of oxidative, proteotoxic, and mitochondrial stress. Neutrophils are a plausible target of this transition because their antimicrobial functions depend on tig...

Rui-Rui Shi, Si-Yue Chen, Ting-Ting Chen et al. · 0 citations

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