Ting-ting Xu

Prophylactic polydatin protects against sepsis-induced muscle atrophy by suppressing endoplasmic reticulum stress via SIRT3 upregulation in a mouse CLP model.

Sepsis-induced muscle atrophy is closely related to the poor prognosis of patients and poses a clinical challenge due to the lack of effective therapies. Polydatin (PD) is a natural phenolic compound possessing great anti-inflammatory property, but its potential effect on sepsis-induced muscle atrophy has not been clar...