Smart Polymer Nanoparticles: Targeting Macrophages/Fibroblasts and Modulating the Microenvironment for Rheumatoid Arthritis Therapy
Abstract Rheumatoid arthritis (RA) is a systemic autoimmune disease associated with a high disability rate. Its core pathogenesis involves immune dysregulation, characterized notably by the aberrant polarization of macrophages toward the pro-inflammatory M1 phenotype, along with the abnormal proliferation and invasion...