Open access
Sep 2026
The intracellular subdomain of the volume-regulated anion channel subunit LRRC8A is a hotspot of channel activation
Volume-regulated anion channels (VRACs), formed by heteromers of LRRC8 subunits, mediate the transport of anions and organic osmolytes in numerous physiological processes. Although their gating mechanism remains poorly understood, conformational rearrangements of the cytosolic leucine-rich repeat domains (LRRDs) have b...
Sara Bertelli, Lu Wang, Malte Klüssendorf et al.
· Nature Communications · 1 citation