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Todd O. Yeates

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Open access Oct 2026

Design of full-length agonist and antagonist antibodies for hard targets

This study provides the first demonstration of both GPCR agonism and antagonism by de novo designed full-length IgG antibodies, demonstrating that the technology can deliver antibodies with programmable function and key properties expected of lead candidates, opening opportunities for first-in-class therapeutics agains...

R. Aglietti, Ramin Ansari, Peter M. Bowers et al. · 0 citations
Review Open access Jul 2026

Protein engineering: status report

Protein engineering appears to be entering a golden age, defined by a rapidly accelerating pace of progress, even as significant challenges in design, screening, and real-world application remain.

H. Ai, Frances H. Arnold, Doug Barrick et al. · 0 citations

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