Tolbert Osire

Rational design of ancestral L-asparaginase via dynamics-guided engineering for improvement of thermostability and acrylamide mitigation efficiency.

L-asparaginase (ASNase) is used both for treating acute lymphoblastic leukemia and as a processing aid to hydrolyze L-asparagine prior to heating, thereby suppressing acrylamide formation in foods and certain traditional Chinese medicinal materials. Industrial pretreatment, however, typically involves high temperature,...