High-grade gliomas (HGGs) in children and adolescents and young adults (AYA) exhibit distinct biology across the neurodevelopmental spectrum. To dissect tumor-intrinsic molecular characteristics independent of developmental variation, we perform comprehensive proteogenomic analyses of tumors from 112 HGG patients aged...
N. Tignor, M. Koptyra, Shrabanti Chowdhury et al.· Cell Reports Medicine· 0 citations
Mass-spectrometry-based phosphoproteomics now profiles phosphorylation at proteome scale, yet converting site-level measurements into coherent, kinase-centered biology — and into actionable drug discovery decisions — remains a persistent barrier to target nomination, mechanism-of-action confirmation, and resistance m...
Tomer M. Yaron-Barir, Jared L. Johnson, Lewis C. Cantley· Clinical Cancer Research· 0 citations
To define mutation-specific lineage reversion and tumor initiation, Ptf1a-tdTomato mice and multiple KRAS mutants are implemented across several genetic, pharmacologic, and inflammatory perturbations in vivo to deciphering mutation-specific oncogenic trajectories and directing the implementation of KRAS-directed therap...
A. Grimont, David Falvo, W. Sisso et al.· Developmental Cell· 1 citation
INvestigating SIGnaling network of specific cell subpopulation in Heterogeneous Tissue, a new platform technology combining fluorescence-activated cell sorting with ultra-sensitive mass spectrometry to enable phosphoproteomic characterization of rare and discrete cell subpopulations from fixed tissues, uncovered a glob...
Ryuhjin Ahn, Alicia D'Souza, L. Long et al.· bioRxiv· 0 citations
KinoPlex, a computational framework that integrates predicted protein structures and kinase recognition motifs to assign phosphorylation potential and kinase specificity to all serine/threonine/tyrosine residues, is presented.
David Vanderwall, Edward L. Huttlin, J. Mintseris et al.· Nature Biotechnology· 0 citations
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