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Author

Tommy Alain

2 papers indexed here

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Open access Sep 2026

eIF4A inhibition disrupts resistance-associated translational and metabolic programs in BRAF-mutant melanoma

Acquired resistance to mitogen-activated protein kinase (MAPK) pathway inhibitors remains a major barrier to durable control of BRAF-mutant melanoma. Although resistance mechanisms are heterogeneous, they converge on adaptive programs that support survival, phenotypic plasticity, and metabolic fitness. We asked whether...

Alejandro Schcolnik-Cabrera, Meriem Takdenti, Anavasadat Sadr Hashemi Nejad et al. · 0 citations
Open access Jul 2026

Skeletal muscle reprogramming of metabolic, ribosomal and developmental pathways contributes to Roux-en-Y gastric bypass-induced adaptation in women

Summary Background Understanding how skeletal muscle responds to weight loss is crucial for developing targeted strategies to manage obesity and promote sustained improvement in metabolic health. Here, we investigated the molecular mechanisms underlying skeletal muscle reprogramming of gene expression and metabolic act...

Chantal A. Pileggi, Dhanuddara Mohottalage, Luke S. Kennedy et al. · 0 citations

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