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Author

Tomohiro Kuroda

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Open access Sep 2026

Reverse-engineering the diagnostic process: An indirect finding-driven deep learning model for pelvic active bleeding detection on CT that achieves specialist-level performance and surpasses residents - a multicenter study.

Contrast-enhanced computed tomography (CT) is useful for detecting active bleeding in patients with pelvic trauma. However, early detection of active bleeding from CT images is challenging due to the extensive image volume, which can delay intervention. Although the development of accurate and rapid detection support s...

Naoki Okada, Shusuke Inoue, Y. Hirano et al. · 0 citations
Review Open access Aug 2026

Recommendations for generating real-world evidence with regulatory-grade relevance and reliability

A purpose-oriented framework clarifying the levels of relevance and reliability required according to specific regulatory objectives is proposed, and practical recommendations for generating regulatory-grade RWE that meaningfully informs regulatory decision-making while complementing conventional clinical trials are pr...

Yasutoshi Sakamoto, H. Bando, Yoshihiro Aoyagi et al. · 0 citations

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