Preprint
Sep 2026
A flexible framework for treatment effect inference in longitudinal clinical studies with skewed outcomes
Longitudinal continuous outcomes in clinical trials are commonly analyzed using mixed models for repeated measures (MMRM) under normality assumptions. However, many clinical outcomes are skewed, making mean-based treatment effects difficult to interpret and potentially reducing statistical efficiency. The Box--Cox MMRM...
K. Maruo, Ryota Ishii, Yusuke Yamaguchi et al.
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