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Author

Tong-De Du

2 papers indexed here

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Open access Sep 2026

HERC4-mediated ubiquitination licenses RIPK1 to initiate TNF-induced cell death.

TNF can activate both prosurvival and prodeath signaling downstream of tumor necrosis factor receptor 1 (TNFR1). Survival signaling originates from TNFR1-containing membrane-bound complex I, while death signaling is driven by cytosolic complex II. Receptor-interacting protein kinase 1 (RIPK1) is a central component of...

Hao-Hao Lu, Tong-De Du, Lin Li et al. · 0 citations
Open access Sep 2026

USP10 stabilizes FOXM1 through KAT5-mediated acetylation to suppress cell senescence and promote melanoma malignant progression

The ubiquitin signaling cascade plays a pivotal role in multiple cancer types, yet its role in melanoma progression remains incompletely elucidated. An unbiased and systematic analysis indicates that Ubiquitin-specific peptidase 10 (USP10), a member of USP gene family, was top priority prognostic signature for primary...

Zhi-Yuan Qiu, Cheng-Lian Sun, Juan Wang et al. · 0 citations

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