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Tong-Tong Zhang

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Open access Aug 2026

Berberine alleviates postoperative cognitive dysfunction by suppressing microglial IDO1 induction and kynurenine pathway activation in aged mice.

Postoperative cognitive dysfunction (POCD) is a common complication of surgery in elderly patients, and no pharmacological therapy has been approved. Although indoleamine 2,3-dioxygenase 1 (IDO1)-driven kynurenine pathway activation has been linked to perioperative neurocognitive impairment, neither the cellular source...

Jia-Lin Yang, Xiaohong Liu, Tong-Tong Zhang et al. · 0 citations

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