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Author

Tong Yu

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Open access Oct 2026

A tandem repeat in TCF25 intron 1 is associated with MC1R activation through dual mechanisms of transcriptional derepression and chromatin looping underlying black plumage in chickens.

Plumage pigmentation in chickens offers important insights into the genetic basis of phenotypic diversification. Although melanocortin-1 receptor gene (MC1R) is a central regulator of melanogenesis, the regulatory mechanisms contributing to extended black plumage remain incompletely understood. In this study, we integr...

Xue Wu, L. Rong, Tong Yu et al. · 0 citations
Oct 2026

Mevalonate Metabolism Orchestrates Platelet Hyperactivation via Protein Prenylation to Aggravate Septic Thrombosis.

Sepsis is a life-threatening systemic inflammatory disorder that triggers disseminated intravascular coagulation and microthrombosis, in which exaggerated platelet activation exacerbates disease progression. The mevalonate pathway is responsible for the biosynthesis of vital isoprenoids and sterols, also playing an imp...

Hao-Jie Jiang, Mi-Na Yang, Tong Yu et al. · 0 citations

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